Skip to main content

Platelet Rich Plasma (PRP) for Treatment of Chronic Non Healing Ulcer

During my residency, I was regularly posted in the Blood Bank for my thesis project. My mentor, Dr. Dharmesh Chandra Sharma (retd. Blood bank in-charge), along with the thesis work also included me in a lot of fine research projects which he used to conduct in the blood bank.

Hereby, I am discussing one of the case projects we did together.

A wound refers to a sharp injury which damages the dermis of the skin. Wounds that have impaired healing process enter a state of pathological inflammation. Non-healing wounds result in enormous expenditures in healthcare. Chronic wounds are of various types such as venous leg ulcers, ischemic wounds, diabetic foot ulcers, ischemic wounds and pressure wounds (bed sores/ pressure ulcers).

Bed sores/pressure ulcers are a very common problem in bed ridden patients. Some patients develop resistance to the antibiotics resulting in progression of the ulcer to higher grades which might lead to tissue necrosis, damage to bones, joints and even life threatening infections.

Presently, for pressure ulcers standard treatment of choice is pressure relief, surgical debridement and treatment with local and systemic antibiotics. In this case study we used PRP dressing for the treatment of chronic non healing ulcer (bed sore/ pressure ulcer).

Platelet rich plasma (PRP) also called as autologous platelet gel is rich in growth factors. It is essentially an increased concentration of autologous platelets suspended in small amount of plasma after centrifugation.

Platelets help in hemostasis and consist of growth factors stored in α- granules. These are platelet derived growth factor (PDGF), insulin like growth factor (IGF), vascular endothelial growth factor (VEGF), platelet derived angiogenic factor (PDAF) and transforming growth factor -beta (TGF-β).

Growth factors are involved in key stages of wound healing and regenerative process including chemotaxis, proliferation, differentiation and angiogenesis. Along with these growth factors platelets also release fibronectin, vitronectin, sphingosine 1 phosphate etc. which promotes wound healing.

Our case study was a 22 years old male having lower limb paresis. He was suffering from non-healing wound on left buttock as he got bed ridden after a prior surgery which was not responding to conventional treatments with local and systemic antibiotics. Dermatology consultation and guidance was taken for in depth approach of the patient from a renowned dermatologist Dr. Khozema Saify. At the time of presentation the ulcer was 5x4 cm in size and 1.5 cm in depth.

For PRP dressing the wound was cleaned thoroughly with spirit and local dressing with platelet rich plasma was applied to the patient every alternate day for one month. For each dressing fresh pad of PRP was used and was kept on the wound for 30 minutes till it got absorbed.  

Then, it was covered with perforated glacial paper and pressure dressing was done using cotton and bandage. No local or systemic antibiotic was given to the patient during the treatment.

After 15 dressings the wound was completely healed. Hence, PRP dressing proved beneficial in prevention of further complications and infection in the patient.

This way of treatment has been mentioned in literature as well as by few clinicians.  

This case report co-authored by me has already been published in a journal in 2016.

This is my personal blog hence I've not put any references here but if any one wants to visit the link to the original case report do leave a comment below.

I decided to share about PRP due to it's increasing demand in healthcare as well as skincare industry. 

All the procedures were done with consultation and under supervision of experienced doctors. 

Take care 🙂

For more updates follow me on intagram <3


Comments

Popular posts from this blog

APHERESIS FAQs

APHERESIS - YouTube Video in Hindi Q. What is Apheresis ? A. It is a procedure in which a particular component of blood is collected and the remainder of the blood is returned to the donor with the help of an automated machine. Q. How does Apheresis works? A. Blood is separated into various components based on their specific gravity by centrifugal force. In a closed system, blood flows from the donor’s arm into the centrifuge bowl, where a specific component is removed and the remaining blood is returned to the donor. It can be a continous or intermittent flow. In intermittent flow blood is removed through a venepuncture, centrifuged and returned in alternating steps to the same venepuncture. In continous flow, blood is removed by one venepuncture in one arm and returned through another venepuncture in the other arm. Q. How long does it take for the procedure to take place? A. It might take 30 minutes to 2 hours depending on the requirements and donor’s sta

How Sugar Affects Your Skin: Sugar and Skin Health | Acne | Inflammation

Hey!! Thank you for stopping by ☺ Hope you are doing great. In this blog post I will be discussing about how sugar affects the skin health. When going to a sweet shop, my senses becomes all aggravated by the smell, texture and the aesthetic appearance of the items. There is no denying that I am myself a big sweet tooth and loves indulging in various kinds of desserts from time to time. The sweet stuff definitely tastes absolutely delicious which results in more cravings but can cause a lot of problems in our body including our skin health. For me sugar was playing a huge role in the inflammation going on in my body leading to acne. I’ve suffered from both acne and rosacea . I still get hormonal breakouts from time to time but limiting sugar in my diet has drastically affected my skin health. I have noticed that whenever I overindulge in my favorite sweets my acne is aggravated and my skin becomes oilier. Sugar is an inflammatory food; hence it result

Acne Vulgaris: Pathogenesis, Causes, Treatment

PICTURE CREDITS- PEXELS.COM Acne is a skin condition that is seen predominantly in adolescents. They can also been seen in adults due to hormonal changes referred to as Adult acne. Acne is a chronic inflammatory disease of the pilosebaceous filaments that is typically seen on the face, neck, upper arms and upper body as well. They can be inflammatory or noninflammatory types Non-inflammatory These include blackheads and whiteheads which are also called comedones. When the follicles get clogged and are exposed to the environment it turns black which is also known as open comedones or blackheads. When the comedones are closed they are referred to as whiteheads. Inflammatory These include various types such as papules, pustules, nodules, cysts or nodulocystic acne. Inflammatory acne presents with redness swelling of the surrounding area and are painful in nature. What are sebaceous glands? These are holocrine glands which occur in conjunction of the hair follicle unit also kno