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Showing posts from June, 2020

The Secretor Status

The ABO blood group and secretor status of individuals is inherited independently. ABO blood group antigens are inherited by A, B & H genes and gene responsible for secretor state is Se (Se/Se & Se/se) gene. If recessive gene se/se is inherited person is non secretor. These group specific substances, ABH may be detected in most body fluid as soluble form in secretors except cerebrospinal fluid (CSF). One of the richest and most available source is saliva . Secretor status of a person can be quite useful to determine certain doubtful cases of ABO blood grouping and also has clinical significance. In simple terms, secretors are individuals which secrete their blood type antigens in their body fluids such as saliva, mucus etc and non secretors are people who does not or put a very little amount in them. Approximately 80% of the people are Secretors. In forensic work, a person ’ s blood type can be ascertained from very small traces of blood found at a crime scene. In

Platelet Rich Plasma (PRP) for Treatment of Chronic Non Healing Ulcer

During my residency, I was regularly posted in the Blood Bank for my thesis project. My mentor, Dr. Dharmesh Chandra Sharma (retd. Blood bank in-charge), along with the thesis work also included me in a lot of fine research projects which he used to conduct in the blood bank. Hereby, I am discussing one of the case projects we did together. A wound refers to a sharp injury which damages the dermis of the skin. Wounds that have impaired healing process enter a state of pathological inflammation. Non-healing wounds result in enormous expenditures in healthcare. Chronic wounds are of various types such as venous leg ulcers, ischemic wounds, diabetic foot ulcers, ischemic wounds and pressure wounds (bed sores/ pressure ulcers). Bed sores/pressure ulcers are a very common problem in bed ridden patients. Some patients develop resistance to the antibiotics resulting in progression of the ulcer to higher grades which might lead to tissue necrosis, damage to bones, joints and